| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 1 |
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| Ligand | BDBM50076746 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_50975 |
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| Ki | 4.6±n/a nM |
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| Citation |  Cocuzza, AJ; Hobbs, FW; Arnold, CR; Chidester, DR; Yarem, JA; Culp, S; Fitzgerald, L; Gilligan, PJ 4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists. Bioorg Med Chem Lett9:1057-62 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin-releasing factor receptor 1 |
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| Name: | Corticotropin-releasing factor receptor 1 |
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| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 50744.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34998 |
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| Residue: | 444 |
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| Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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| BDBM50076746 |
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| n/a |
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| Name | BDBM50076746 |
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| Synonyms: | 1-(3-Bromo-4-{ethyl-[4-methyl-6-(2-trifluoromethyl-phenyl)-pyrimidin-2-yl]-amino}-phenyl)-ethanone | CHEMBL436978 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19BrF3N3O |
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| Mol. Mass. | 478.305 |
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| SMILES | CCN(c1nc(C)cc(n1)-c1ccccc1C(F)(F)F)c1ccc(cc1Br)C(C)=O |
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| Structure | 
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