Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50076904 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_51119 (CHEMBL665732) | ||
| Ki | 45±n/a nM | ||
| Citation |  Beck, JP; Curry, MA; Chorvat, RJ; Fitzgerald, LW; Gilligan, PJ; Zaczek, R; Trainor, GL Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists. Bioorg Med Chem Lett9:1185-8 (1999) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM50076904 | |||
| n/a | |||
| Name | BDBM50076904 | ||
| Synonyms: | 3-(2-Bromo-4-isopropyl-phenyl)-7-(di-sec-butyl-amino)-5-methyl-3H-thiazolo[4,5-d]pyrimidine-2-thione | CHEMBL18173 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H31BrN4S2 | ||
| Mol. Mass. | 507.553 | ||
| SMILES | CCC(C)N(C(C)CC)c1nc(C)nc2n(-c3ccc(cc3Br)C(C)C)c(=S)sc12 |(11.24,-9.46,;12.59,-10.23,;12.59,-11.75,;11.26,-12.52,;13.92,-12.52,;15.25,-11.75,;16.6,-12.52,;15.25,-10.21,;16.59,-9.43,;13.93,-14.06,;12.59,-14.83,;12.59,-16.39,;11.26,-17.16,;13.93,-17.16,;15.28,-16.37,;16.75,-16.85,;17.23,-18.3,;16.2,-19.45,;16.68,-20.92,;18.19,-21.22,;19.22,-20.06,;18.71,-18.62,;19.83,-17.52,;18.68,-22.69,;17.66,-23.84,;20.18,-23,;17.65,-15.6,;19.19,-15.6,;16.73,-14.35,;15.27,-14.83,)| | ||
| Structure | 
| ||