| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-nucleotidase |
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| Ligand | BDBM50522286 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1886270 (CHEMBL4387947) |
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| Ki | 1000000±n/a nM |
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| Citation |  Guillon, R; Rahimova, R; Preeti, na; Egron, D; Rouanet, S; Dumontet, C; Aghajari, N; Jordheim, LP; Chaloin, L; Peyrottes, S Lead optimization and biological evaluation of fragment-based cN-II inhibitors. Eur J Med Chem168:28-44 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-nucleotidase |
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| Name: | 5'-nucleotidase |
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| Synonyms: | 5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE |
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| Type: | Enzyme |
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| Mol. Mass.: | 63371.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21589 |
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| Residue: | 574 |
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| Sequence: | MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
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| BDBM50522286 |
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| n/a |
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| Name | BDBM50522286 |
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| Synonyms: | CHEMBL3237671 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14N3Na2O8P |
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| Mol. Mass. | 381.1868 |
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| SMILES | [Na;v0+].[Na;v0+].[H][C@@]1([#8]-[#6@H](-[#6@H](-[#8])-[#6@@H]1-[#8])-n1ccc(-[#7])nc1=O)[#6@H](-[#8])-[#6]P([#8-])([#8-])=O |r| |
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| Structure | 
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