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Target5'-nucleotidase
LigandBDBM68391
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1886269 (CHEMBL4387946)
Ki 900000±n/a nM
Citation Guillon, R; Rahimova, R; Preeti, na; Egron, D; Rouanet, S; Dumontet, C; Aghajari, N; Jordheim, LP; Chaloin, L; Peyrottes, S Lead optimization and biological evaluation of fragment-based cN-II inhibitors. Eur J Med Chem168:28-44 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5'-nucleotidase
Name:5'-nucleotidase
Synonyms:5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE
Type:Enzyme
Mol. Mass.:63371.54
Organism:Homo sapiens (Human)
Description:P21589
Residue:574
Sequence:
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM68391
n/a
NameBDBM68391
Synonyms:(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol | (2R,3S,4S,5R)-2-(6-amino-2-fluoro-purin-9-yl)-5-methylol-tetrahydrofuran-3,4-diol | (2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | (2R,3S,4S,5R)-2-(6-azanyl-2-fluoranyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | FLUDARABINE | FLUDARABINE PHOSPHATE | MLS000028687 | SMR000058874 | cid_657237 | fludara
TypeSmall organic molecule
Emp. Form.C10H12FN5O4
Mol. Mass.285.2318
SMILESNc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
Structure
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