Reaction Details |
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Target | TYR_PHOSPHATASE_2 domain-containing protein |
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Ligand | BDBM50501239 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1886957 (CHEMBL4388634) |
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IC50 | 1500±n/a nM |
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Citation | Washburn, A; Abdeen, S; Ovechkina, Y; Ray, AM; Stevens, M; Chitre, S; Sivinski, J; Park, Y; Johnson, J; Hoang, QQ; Chapman, E; Parish, T; Johnson, SM Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections. Bioorg Med Chem Lett29:1665-1672 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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TYR_PHOSPHATASE_2 domain-containing protein |
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Name: | TYR_PHOSPHATASE_2 domain-containing protein |
Synonyms: | (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB |
Type: | Hydrolase |
Mol. Mass.: | 30152.45 |
Organism: | Mycobacterium tuberculosis |
Description: | n/a |
Residue: | 276 |
Sequence: | MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSRE
VARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSIND
AATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGL
DRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLA
AARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
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BDBM50501239 |
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n/a |
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Name | BDBM50501239 |
Synonyms: | CHEMBL3938421 |
Type | Small organic molecule |
Emp. Form. | C25H19N3O7S2 |
Mol. Mass. | 537.564 |
SMILES | Oc1cccc(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc2cc(NS(=O)(=O)c3cccc(O)c3)ccc2o1 |
Structure |
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