Ki Summary

Reaction Details

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Target

C5a anaphylatoxin chemotactic receptor 1

Ligand

BDBM50077481

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_41605 (CHEMBL650558)

IC50

3020±n/a nM

Citation

Finch, AM; Wong, AK; Paczkowski, NJ; Wadi, SK; Craik, DJ; Fairlie, DP; Taylor, SM Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J Med Chem42:1965-74 (1999) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

C5a anaphylatoxin chemotactic receptor 1

Name:

C5a anaphylatoxin chemotactic receptor 1

Synonyms:

C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88

Type:

Enzyme

Mol. Mass.:

39347.68

Organism:

Homo sapiens (Human)

Description:

P21730

Residue:

350

Sequence:

MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV

BDBM50077481

n/a

Name

BDBM50077481

Synonyms:

(R)-2-[(S)-2-[(R)-2-({(R)-1-[(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-2-amino-acetyl]-pyrrolidine-2-carbonyl}-amino)-3-cyclohexyl-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-5-guanidino-pentanoic acid | CHEMBL2373453

Type

Small organic molecule

Emp. Form.

C44H61N11O8

Mol. Mass.

872.024

SMILES

CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC1CCCCC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(O)=O |wU:38.40,4.3,15.16,wD:23.25,27.28,52.56,(.63,-9.3,;-.25,-7.58,;-2.18,-7.5,;.78,-5.98,;-.09,-4.27,;-2.01,-4.17,;-2.89,-2.47,;-1.86,-.85,;-2.73,.86,;-4.66,.96,;-5.69,-.66,;-4.81,-2.37,;.95,-2.65,;2.86,-2.75,;.5,-.78,;2.14,.22,;2.1,2.13,;3.82,-.71,;3.69,-2.35,;5.24,-.16,;5.61,1.31,;7.15,1.39,;7.7,-.02,;6.51,-1,;7.83,-1.74,;9.12,-1,;7.83,-3.26,;9.12,-4.03,;10.42,-3.19,;11.76,-3.88,;13.35,-3.24,;13.98,-2.07,;14.35,-3.56,;12.71,-4.27,;12.13,-5.36,;9.87,-5.33,;11.41,-5.33,;9.12,-6.65,;10.19,-7.72,;11.66,-7.33,;12.76,-8.42,;12.33,-9.89,;13.88,-10.62,;14.95,-9.54,;16.47,-9.64,;17.31,-8.35,;16.62,-6.97,;15.1,-6.9,;14.25,-8.19,;9.79,-9.2,;8.6,-9.51,;10.86,-10.28,;10.47,-11.75,;11.99,-11.9,;12.61,-13.3,;14.13,-13.45,;14.72,-14.85,;16.24,-15.01,;17.14,-13.78,;16.87,-16.41,;9.57,-12.97,;10.19,-14.37,;8.08,-12.82,)|

Structure