Ki Summary

Reaction Details

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Target

C5a anaphylatoxin chemotactic receptor 1

Ligand

BDBM50077489

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_41605 (CHEMBL650558)

IC50

2951.21±n/a nM

Citation

Finch, AM; Wong, AK; Paczkowski, NJ; Wadi, SK; Craik, DJ; Fairlie, DP; Taylor, SM Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J Med Chem42:1965-74 (1999) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

C5a anaphylatoxin chemotactic receptor 1

Name:

C5a anaphylatoxin chemotactic receptor 1

Synonyms:

C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88

Type:

Enzyme

Mol. Mass.:

39347.68

Organism:

Homo sapiens (Human)

Description:

P21730

Residue:

350

Sequence:

MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV

BDBM50077489

n/a

Name

BDBM50077489

Synonyms:

CHEMBL410692 | N-{3-[(5S,8S,11R,14S,17R,19aS)-8-Benzyl-17-cyclohexylmethyl-5,14-bis-(1H-indol-3-ylmethyl)-9-methyl-4,7,10,13,16,19-hexaoxo-icosahydro-3a,6,9,12,15,18-hexaaza-cyclopentacyclooctadecen-11-yl]-propyl}-guanidine

Type

Small organic molecule

Emp. Form.

C52H65N11O6

Mol. Mass.

940.1426

SMILES

CN1[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC2CCCCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CCCNC(N)=N)C1=O

Structure