Reaction Details | |||
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Target | C5a anaphylatoxin chemotactic receptor 1 | ||
Ligand | BDBM50077486 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_41605 (CHEMBL650558) | ||
IC50 | 1995.26±n/a nM | ||
Citation | Finch, AM; Wong, AK; Paczkowski, NJ; Wadi, SK; Craik, DJ; Fairlie, DP; Taylor, SM Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J Med Chem42:1965-74 (1999) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
C5a anaphylatoxin chemotactic receptor 1 | |||
Name: | C5a anaphylatoxin chemotactic receptor 1 | ||
Synonyms: | C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88 | ||
Type: | Enzyme | ||
Mol. Mass.: | 39347.68 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P21730 | ||
Residue: | 350 | ||
Sequence: |
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BDBM50077486 | |||
n/a | |||
Name | BDBM50077486 | ||
Synonyms: | (R)-2-[(S)-2-[(R)-2-({(R)-1-[(S)-6-Amino-2-((S)-2-methylamino-3-phenyl-propionylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-amino)-3-cyclohexyl-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-5-guanidino-pentanoic acid | CHEMBL2373532 | ||
Type | Small organic molecule | ||
Emp. Form. | C46H67N11O7 | ||
Mol. Mass. | 886.0937 | ||
SMILES | NCCCC[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC1CCCCC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(O)=O |wU:39.41,9.9,wD:24.26,5.5,28.29,53.57,(5.65,-12.11,;6.42,-10.78,;5.65,-9.45,;6.42,-8.12,;5.65,-6.78,;6.42,-5.46,;5.65,-4.13,;4.32,-4.9,;4.32,-6.43,;2.99,-4.13,;1.66,-4.9,;2.99,-2.59,;4.32,-1.82,;4.32,-.28,;5.67,.49,;6.99,-.28,;6.99,-1.82,;5.67,-2.59,;7.75,-6.22,;7.75,-7.76,;9.08,-5.46,;9.47,-3.97,;11.01,-3.88,;11.57,-5.32,;10.37,-6.29,;11.69,-7.06,;13.03,-6.29,;11.69,-8.6,;13.03,-9.37,;14.32,-8.52,;15.69,-9.22,;17.3,-8.56,;17.94,-7.39,;18.3,-8.89,;16.63,-9.61,;16.05,-10.72,;13.79,-10.69,;15.33,-10.69,;13.01,-12.01,;14.11,-13.11,;15.6,-12.71,;16.68,-13.81,;16.27,-15.3,;17.82,-16.04,;18.91,-14.95,;20.45,-15.04,;21.29,-13.74,;20.59,-12.36,;19.06,-12.27,;18.22,-13.58,;13.69,-14.6,;12.5,-14.92,;14.78,-15.7,;14.37,-17.18,;15.91,-17.35,;16.54,-18.75,;18.07,-18.92,;18.68,-20.31,;20.22,-20.48,;21.12,-19.24,;20.84,-21.89,;13.48,-18.43,;14.09,-19.83,;11.94,-18.26,)| | ||
Structure |