Reaction Details | |||
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Target | Amyloid-beta precursor protein | ||
Ligand | BDBM50323197 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1888363 (CHEMBL4390040) | ||
IC50 | >50000±n/a nM | ||
Citation | Sirimangkalakitti, N; Juliawaty, LD; Hakim, EH; Waliana, I; Saito, N; Koyama, K; Kinoshita, K Naturally occurring biflavonoids with amyloid ? aggregation inhibitory activity for development of anti-Alzheimer agents. Bioorg Med Chem Lett29:1994-1997 (2019) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Amyloid-beta precursor protein | |||
Name: | Amyloid-beta precursor protein | ||
Synonyms: | A4 | A4_HUMAN | ABPP | AD1 | AICD-50 | AICD-57 | AICD-59 | AID(50) | AID(57) | AID(59) | APP | APPI | Alzheimer disease amyloid protein | Amyloid beta A4 protein | Amyloid beta Protein | Amyloid beta protein (sAPPbeta) | Amyloid beta protein Abeta(1-42) | Amyloid intracellular domain 50 | Amyloid intracellular domain 57 | Amyloid intracellular domain 59 | Amyloid protein (Abeta42b) | Amyloid β-protein (Aβ42) | Beta amyloid A4 protein | Beta-APP40 | Beta-APP42 | Beta-amyloid protein 40 | Beta-amyloid protein 42 | C31 | C83 | C99 | CVAP | Cerebral vascular amyloid peptide | Gamma Secretase | Gamma-CTF(50) | Gamma-CTF(57) | Gamma-CTF(59) | Gamma-secretase | Gamma-secretase C-terminal fragment 50 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | P3(40) | P3(42) | PN-II | PreA4 | Protease nexin-II | S-APP-alpha | S-APP-beta | Soluble APP-alpha | Soluble APP-beta | beta-Amyloid Precursor Protein (APP) | ||
Type: | Single-pass type I membrane protein | ||
Mol. Mass.: | 86890.41 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P05067 | ||
Residue: | 770 | ||
Sequence: |
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BDBM50323197 | |||
n/a | |||
Name | BDBM50323197 | ||
Synonyms: | 7''-O-methylamentoflavone | CHEMBL450522 | sotetsuflavone | ||
Type | Small organic molecule | ||
Emp. Form. | C31H20O10 | ||
Mol. Mass. | 552.4845 | ||
SMILES | COc1cc(O)c2c(oc(cc2=O)-c2ccc(O)cc2)c1-c1cc(ccc1O)-c1cc(O)c2c(cc(O)cc2=O)o1 |(22.48,-45.72,;23.81,-44.95,;25.14,-45.72,;25.14,-47.26,;26.47,-48.03,;26.47,-49.57,;27.81,-47.26,;27.81,-45.71,;29.14,-44.93,;30.48,-45.71,;30.48,-47.26,;29.14,-48.03,;29.14,-49.57,;31.82,-44.95,;33.14,-45.72,;34.48,-44.95,;34.48,-43.41,;35.82,-42.64,;33.14,-42.64,;31.81,-43.41,;26.47,-44.95,;25.28,-42.99,;23.95,-43.76,;22.62,-42.99,;22.61,-41.46,;23.93,-40.68,;25.28,-41.45,;26.61,-40.67,;21.29,-43.77,;21.29,-45.31,;19.96,-46.09,;19.96,-47.63,;18.62,-45.33,;18.61,-43.78,;17.27,-43.02,;15.95,-43.79,;14.62,-43.02,;15.95,-45.33,;17.28,-46.1,;17.28,-47.64,;19.94,-42.99,)| | ||
Structure |