Reaction Details |
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Target | Glutamate carboxypeptidase 2 |
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Ligand | BDBM50522949 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1888710 (CHEMBL4390387) |
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IC50 | 170±n/a nM |
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Citation | Machulkin, AE; Skvortsov, DA; Ivanenkov, YA; Ber, AP; Kavalchuk, MV; Aladinskaya, AV; Uspenskaya, AA; Shafikov, RR; Plotnikova, EA; Yakubovskaya, RI; Nimenko, EA; Zyk, NU; Beloglazkina, EK; Zyk, NV; Koteliansky, VE; Majouga, AG Synthesis and biological evaluation of PSMA-targeting paclitaxel conjugates. Bioorg Med Chem Lett29:2229-2235 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glutamate carboxypeptidase 2 |
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Name: | Glutamate carboxypeptidase 2 |
Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
Type: | PROTEIN |
Mol. Mass.: | 84333.66 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1497035 |
Residue: | 750 |
Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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BDBM50522949 |
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n/a |
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Name | BDBM50522949 |
Synonyms: | CHEMBL4449364 |
Type | Small organic molecule |
Emp. Form. | C25H35BrN6O8 |
Mol. Mass. | 627.485 |
SMILES | OC(=O)CC[C@H](NC(=O)N[C@@H](CCCCN(Cc1ccc(Br)cc1)C(=O)CCCCCN=[N+]=[N-])C(O)=O)C(O)=O |r| |
Structure |
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