| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sphingosine kinase 1 |
|---|
| Ligand | BDBM50523505 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1890496 (CHEMBL4392250) |
|---|
| IC50 | 41±n/a nM |
|---|
| Citation |  Adams, DR; Tawati, S; Berretta, G; Rivas, PL; Baiget, J; Jiang, Z; Alsfouk, A; Mackay, SP; Pyne, NJ; Pyne, S Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2. J Med Chem62:3658-3676 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sphingosine kinase 1 |
|---|
| Name: | Sphingosine kinase 1 |
|---|
| Synonyms: | SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42521.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NYA1 |
|---|
| Residue: | 384 |
|---|
| Sequence: | MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
|
|
|
|---|
| BDBM50523505 |
|---|
| n/a |
|---|
| Name | BDBM50523505 |
|---|
| Synonyms: | CHEMBL4551903 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H28FNO3 |
|---|
| Mol. Mass. | 421.5038 |
|---|
| SMILES | OC[C@H]1CCCN1Cc1ccc(COc2cccc(OCc3ccccc3F)c2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
