Reaction Details |
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Target | Protein arginine N-methyltransferase 5 |
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Ligand | BDBM50523656 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1890808 (CHEMBL4392562) |
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IC50 | 1.3±n/a nM |
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Citation | Lin, H; Luengo, JI Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors. Bioorg Med Chem Lett29:1264-1269 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein arginine N-methyltransferase 5 |
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Name: | Protein arginine N-methyltransferase 5 |
Synonyms: | 72 kDa ICln-binding protein | ANM5_HUMAN | HRMT1L5 | Histone-arginine N-methyltransferase PRMT5 | IBP72 | JBP1 | Jak-binding protein 1 | PRMT5 | PRMT5/MEP50 complex | Protein arginine N-methyltransferase 5 (PRMT5) | Protein arginine methyltransferase 5 (PRMT5) | SKB1 | SKB1 homolog | SKB1Hs | Shk1 kinase-binding protein 1 homolog |
Type: | Enzyme |
Mol. Mass.: | 72679.99 |
Organism: | Homo sapiens (Human) |
Description: | O14744 |
Residue: | 637 |
Sequence: | MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAK
NRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLP
AFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYS
GEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNK
KGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELF
AKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQV
LMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDM
REWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKL
YNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEF
PVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICV
RFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
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BDBM50523656 |
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n/a |
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Name | BDBM50523656 |
Synonyms: | CHEMBL4579773 |
Type | Small organic molecule |
Emp. Form. | C21H24N6O2 |
Mol. Mass. | 392.4543 |
SMILES | Cc1cnc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)ccn12 |r| |
Structure |
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