| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D(4) dopamine receptor |
|---|
| Ligand | BDBM50079153 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_60658 (CHEMBL671695) |
|---|
| Ki | 0.64±n/a nM |
|---|
| Citation |  Carling, RW; Moore, KW; Moyes, CR; Jones, EA; Bonner, K; Emms, F; Marwood, R; Patel, S; Patel, S; Fletcher, AE; Beer, M; Sohal, B; Pike, A; Leeson, PD 1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels. J Med Chem42:2706-15 (1999) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D(4) dopamine receptor |
|---|
| Name: | D(4) dopamine receptor |
|---|
| Synonyms: | D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48373.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P21917 |
|---|
| Residue: | 419 |
|---|
| Sequence: | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
|
|
|
|---|
| BDBM50079153 |
|---|
| n/a |
|---|
| Name | BDBM50079153 |
|---|
| Synonyms: | 1-[1-(3-Methoxy-benzyl)-piperidin-4-yl]-5-methyl-4-phenyl-1,3-dihydro-imidazol-2-one | CHEMBL91155 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27N3O2 |
|---|
| Mol. Mass. | 377.4794 |
|---|
| SMILES | COc1cccc(CN2CCC(CC2)n2c(C)c([nH]c2=O)-c2ccccc2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
