Reaction Details |
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Target | Leucine--tRNA ligase |
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Ligand | BDBM50524355 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1892859 (CHEMBL4394780) |
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Ki | 21±n/a nM |
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Citation | Nautiyal, M; De Graef, S; Pang, L; Gadakh, B; Strelkov, SV; Weeks, SD; Van Aerschot, A Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases. Eur J Med Chem173:154-166 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Leucine--tRNA ligase |
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Name: | Leucine--tRNA ligase |
Synonyms: | 6.1.1.4 | LeuRS | Leucine--tRNA ligase | Leucyl-tRNA synthetase | SYL_ECOLI | leuS |
Type: | PROTEIN |
Mol. Mass.: | 97211.51 |
Organism: | Escherichia coli (strain K12) |
Description: | ChEMBL_117811 |
Residue: | 860 |
Sequence: | MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGD
VIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYD
WSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCD
TKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYD
NTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEK
KGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVI
LAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDW
GVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNG
MPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLY
FRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGR
IVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQE
SGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQ
TFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEG
DIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLD
GVTVRKVIYVPGKLLNLVVG
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BDBM50524355 |
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n/a |
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Name | BDBM50524355 |
Synonyms: | CHEMBL4467328 |
Type | Small organic molecule |
Emp. Form. | C15H24N4O9S |
Mol. Mass. | 436.437 |
SMILES | CC(C)C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r| |
Structure |
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