| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50524469 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1893502 (CHEMBL4395423) |
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| Ki | 2106±n/a nM |
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| Citation |  Cornelio, B; Laronze-Cochard, M; Miambo, R; De Grandis, M; Riccioni, R; Borisova, B; Dontchev, D; Machado, C; Ceruso, M; Fontana, A; Supuran, CT; Sapi, J 5-Arylisothiazol-3(2H)-one-1,(1)-(di)oxides: A new class of selective tumor-associated carbonic anhydrases (hCA IX and XII) inhibitors. Eur J Med Chem175:40-48 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50524469 |
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| n/a |
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| Name | BDBM50524469 |
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| Synonyms: | CHEMBL4465528 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N2O4S2 |
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| Mol. Mass. | 428.524 |
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| SMILES | CC(C)(C)N1[S+]([O-])C(=CC1=O)c1cn(c2ccccc12)S(=O)(=O)c1ccccc1 |c:7| |
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| Structure | 
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