| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 alpha |
|---|
| Ligand | BDBM50524512 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1893921 (CHEMBL4395842) |
|---|
| IC50 | 1337±n/a nM |
|---|
| Citation |  Heider, F; Ansideri, F; Tesch, R; Pantsar, T; Haun, U; Döring, E; Kudolo, M; Poso, A; Albrecht, W; Laufer, SA; Koch, P Pyridinylimidazoles as dual glycogen synthase kinase 3?/p38? mitogen-activated protein kinase inhibitors. Eur J Med Chem175:309-329 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glycogen synthase kinase-3 alpha |
|---|
| Name: | Glycogen synthase kinase-3 alpha |
|---|
| Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 50991.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49840 |
|---|
| Residue: | 483 |
|---|
| Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
|
|
|
|---|
| BDBM50524512 |
|---|
| n/a |
|---|
| Name | BDBM50524512 |
|---|
| Synonyms: | CHEMBL4589431 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17FN4O2S |
|---|
| Mol. Mass. | 384.427 |
|---|
| SMILES | C[S+]([O-])c1nc(c([nH]1)-c1ccnc(NC(=O)C2CC2)c1)-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
