| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 2 |
|---|
| Ligand | BDBM50525189 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1896018 (CHEMBL4398053) |
|---|
| IC50 | 2900±n/a nM |
|---|
| Citation |  Giraudo, A; Krall, J; Bavo, F; Nielsen, B; Kongstad, KT; Rolando, B; De Blasio, R; Gloriam, DE; Löffler, R; Thiesen, L; Harpsøe, K; Frydenvang, K; Boschi, D; Wellendorph, P; Lolli, ML; Jensen, AA; Frølund, B Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at ?-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters. J Med Chem62:5797-5809 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent GABA transporter 2 |
|---|
| Name: | Sodium- and chloride-dependent GABA transporter 2 |
|---|
| Synonyms: | GABA transporter 2 | GAT2 | S6A13_HUMAN | SLC6A13 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 68012.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1454197 |
|---|
| Residue: | 602 |
|---|
| Sequence: | MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPY
LCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQM
IVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENAT
SPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATF
PYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTAL
GSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI
AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLI
LGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNI
EDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS
SMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELES
HC
|
|
|
|---|
| BDBM50525189 |
|---|
| n/a |
|---|
| Name | BDBM50525189 |
|---|
| Synonyms: | CHEMBL4458674 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C5H8N2O2 |
|---|
| Mol. Mass. | 128.1292 |
|---|
| SMILES | OC(=O)CC1CNC=N1 |c:7| |
|---|
| Structure | 
|
|---|
Search and Browse
