| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Ligand | BDBM50182491 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1897476 (CHEMBL4399511) |
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| IC50 | 13000±n/a nM |
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| Citation |  Othman, MA; Yuyama, K; Murai, Y; Igarashi, Y; Mikami, D; Sivasothy, Y; Awang, K; Monde, K Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett10:1154-1158 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Synonyms: | 2.7.8.27 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | Protein Mob | SMS1_MOUSE | Sgms1 | Sphingomyelin synthase 1 | Tmem23 | Transmembrane protein 23 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49331.73 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_119158 |
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| Residue: | 419 |
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| Sequence: | MLSARTMKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLYRVSS
DNGQRLLDMIETLKMEHHMEAHKNGHANGHLSIGVDIPNPDGSFSIKTKPNGMPNGFRKE
MIKIPMPEPERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFF
DHFNRVQWAFSICEINGMILVGLWLFQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTT
LPVPGMHFNCSPKLFGDWEAQVRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYL
FIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQ
VLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
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| BDBM50182491 |
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| n/a |
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| Name | BDBM50182491 |
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| Synonyms: | CHEBI:69015 | Malabaricone C |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26O5 |
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| Mol. Mass. | 358.4281 |
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| SMILES | Oc1ccc(CCCCCCCCC(=O)c2c(O)cccc2O)cc1O |
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| Structure | 
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