| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Ligand | BDBM50182487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1897471 (CHEMBL4399506) |
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| IC50 | 4000±n/a nM |
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| Citation |  Othman, MA; Yuyama, K; Murai, Y; Igarashi, Y; Mikami, D; Sivasothy, Y; Awang, K; Monde, K Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett10:1154-1158 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Synonyms: | SGMS2 | SMS2 | SMS2_HUMAN | Sphingomyelin synthase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42294.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108027 |
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| Residue: | 365 |
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| Sequence: | MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYI
QIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFFDY
IDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLP
VPGMHFQCAPKLNGDSQAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFI
KEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTIDVIIAYYITTRLFWWYHSMANEKNL
KVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGED
NEKST
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| BDBM50182487 |
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| n/a |
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| Name | BDBM50182487 |
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| Synonyms: | Malabaricone A |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26O3 |
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| Mol. Mass. | 326.4293 |
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| SMILES | Oc1cccc(O)c1C(=O)CCCCCCCCc1ccccc1 |
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| Structure | 
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