| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50081057 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48696 |
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| IC50 | >1000000±n/a nM |
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| Citation |  Greenlee, ML; Laub, JB; Balkovec, JM; Hammond, ML; Hammond, GG; Pompliano, DL; Epstein-Toney, JH Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase. Bioorg Med Chem Lett9:2549-54 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC |
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| Type: | Protien |
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| Mol. Mass.: | 41561.62 |
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| Organism: | Escherichia coli |
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| Description: | P00811 |
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| Residue: | 377 |
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| Sequence: | MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWG
YADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGI
TLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVK
PSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVK
STIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSII
NGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNY
PNPARVDAAWQILNALQ
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|
|
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| BDBM50081057 |
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| n/a |
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| Name | BDBM50081057 |
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| Synonyms: | (R)-2-Benzoylsulfanyl-3-phenyl-propionic acid | CHEMBL315343 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14O3S |
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| Mol. Mass. | 286.346 |
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| SMILES | OC(=O)[C@@H](Cc1ccccc1)SC(=O)c1ccccc1 |
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| Structure | 
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