Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium-dependent serotonin transporter | ||
| Ligand | BDBM50526029 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1898946 (CHEMBL4401061) | ||
| Ki | 103±n/a nM | ||
| Citation |  ?lifirski, G; Król, M; Kleps, J; Ulenberg, S; Belka, M; B?czek, T; Siwek, A; Stachowicz, K; Szewczyk, B; Nowak, G; Bojarski, A; Kozio?, AE; Tur?o, J; Herold, F Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT Eur J Med Chem166:144-158 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium-dependent serotonin transporter | |||
| Name: | Sodium-dependent serotonin transporter | ||
| Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 70168.43 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | P31652 | ||
| Residue: | 630 | ||
| Sequence: |
| ||
| BDBM50526029 | |||
| n/a | |||
| Name | BDBM50526029 | ||
| Synonyms: | CHEMBL4587833 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H31ClN4O2 | ||
| Mol. Mass. | 527.056 | ||
| SMILES | Clc1ccccc1-c1c2ccccn2c(=O)n(CCCCN2CCCC(C2)c2c[nH]c3ccccc23)c1=O |(10.92,-18.52,;9.59,-17.75,;9.59,-16.21,;8.26,-15.43,;6.92,-16.21,;6.92,-17.74,;8.25,-18.51,;8.24,-20.05,;6.91,-20.81,;5.58,-20.04,;4.25,-20.81,;4.25,-22.35,;5.58,-23.12,;6.91,-22.35,;8.23,-23.13,;8.22,-24.67,;9.57,-22.37,;10.9,-23.14,;12.24,-22.38,;13.56,-23.16,;14.9,-22.4,;16.23,-23.17,;17.56,-22.41,;18.89,-23.19,;18.88,-24.73,;17.53,-25.49,;16.21,-24.71,;17.52,-27.03,;16.27,-27.92,;16.73,-29.39,;18.27,-29.41,;19.28,-30.56,;20.79,-30.25,;21.28,-28.79,;20.26,-27.64,;18.76,-27.95,;9.57,-20.83,;10.91,-20.06,)| | ||
| Structure | 
| ||