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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 1A | ||
| Ligand | BDBM50526031 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1898945 (CHEMBL4401060) | ||
| Ki | 69±n/a nM | ||
| Citation |  ?lifirski, G; Król, M; Kleps, J; Ulenberg, S; Belka, M; B?czek, T; Siwek, A; Stachowicz, K; Szewczyk, B; Nowak, G; Bojarski, A; Kozio?, AE; Tur?o, J; Herold, F Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT Eur J Med Chem166:144-158 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 1A | |||
| Name: | 5-hydroxytryptamine receptor 1A | ||
| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A | ||
| Type: | n/a | ||
| Mol. Mass.: | 46122.49 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 422 | ||
| Sequence: |
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| BDBM50526031 | |||
| n/a | |||
| Name | BDBM50526031 | ||
| Synonyms: | CHEMBL4470492 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H36N4O4 | ||
| Mol. Mass. | 552.6633 | ||
| SMILES | COc1ccc2[nH]cc(C3CCCN(CCCCn4c(=O)c(-c5ccccc5OC)c5ccccn5c4=O)C3)c2c1 |(48.24,-29.68,;47.22,-28.53,;45.71,-28.84,;45.22,-30.31,;43.71,-30.61,;42.7,-29.46,;41.16,-29.45,;40.7,-27.98,;41.95,-27.08,;41.96,-25.54,;43.31,-24.79,;43.32,-23.25,;41.99,-22.46,;40.66,-23.23,;39.33,-22.45,;38,-23.21,;36.67,-22.43,;35.33,-23.2,;34,-22.42,;34,-20.88,;35.34,-20.12,;32.67,-20.1,;32.68,-18.56,;31.35,-17.8,;31.35,-16.26,;32.69,-15.49,;34.02,-16.26,;34.02,-17.8,;35.35,-18.57,;36.69,-17.81,;31.34,-20.87,;30.01,-20.09,;28.69,-20.87,;28.69,-22.41,;30.01,-23.17,;31.34,-22.41,;32.66,-23.18,;32.65,-24.72,;40.64,-24.77,;43.19,-28,;44.69,-27.69,)| | ||
| Structure | 
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