| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 1 |
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| Ligand | BDBM50020883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1899621 (CHEMBL4401736) |
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| IC50 | 5960±n/a nM |
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| Citation |  Kern, F; Wanner, KT Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors ?-aminobutyric acid transporter 1. Bioorg Med Chem27:1232-1245 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 1 |
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| Name: | Sodium- and chloride-dependent GABA transporter 1 |
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| Synonyms: | GABA transporter 1 | GABATR | GABT1 | GAT-1 | GAT1 | SC6A1_HUMAN | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Solute carrier family 6 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67079.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1454196 |
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| Residue: | 599 |
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| Sequence: | MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI
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| BDBM50020883 |
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| n/a |
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| Name | BDBM50020883 |
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| Synonyms: | (R)-Piperidine-3-carboxylic acid | (R)-nipecotic acid | CHEMBL77575 | Nipecotic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C6H11NO2 |
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| Mol. Mass. | 129.157 |
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| SMILES | OC(=O)[C@@H]1CCCNC1 |r| |
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| Structure | 
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