Reaction Details |
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Target | Retinoic acid receptor alpha |
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Ligand | BDBM50526312 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1899797 (CHEMBL4401912) |
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EC50 | 16±n/a nM |
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Citation | Goncalves, MB; Clarke, E; Jarvis, CI; Barret Kalindjian, S; Pitcher, T; Grist, J; Hobbs, C; Carlstedt, T; Jack, J; Brown, JT; Mills, M; Mumford, P; Borthwick, AD; Corcoran, JPT Discovery and lead optimisation of a potent, selective and orally bioavailable RAR? agonist for the potential treatment of nerve injury. Bioorg Med Chem Lett29:995-1000 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinoic acid receptor alpha |
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Name: | Retinoic acid receptor alpha |
Synonyms: | Nr1b1 | RARA_MOUSE | Rara |
Type: | PROTEIN |
Mol. Mass.: | 50742.79 |
Organism: | Mus musculus |
Description: | ChEMBL_195182 |
Residue: | 462 |
Sequence: | MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTSLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFDVGMSKESVRNDRNKKKKEAPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDKVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQSGGGTRDGGGLAPPPGSCSPSLSPSSHRSSPATQSP
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BDBM50526312 |
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n/a |
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Name | BDBM50526312 |
Synonyms: | CHEMBL4449668 | US10752616, Code No. BHBA-007 |
Type | Small organic molecule |
Emp. Form. | C19H13FN2O4 |
Mol. Mass. | 352.3159 |
SMILES | Cc1ccc(C)c2oc(cc12)-c1nc(no1)-c1ccc(C(O)=O)c(F)c1 |
Structure |
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