| Reaction Details |
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 | Report a problem with these data |
| Target | Polyphenol oxidase 2 |
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| Ligand | BDBM50526625 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1900392 (CHEMBL4402614) |
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| IC50 | 2600±n/a nM |
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| Citation |  Kim, JY; Kim, JY; Jenis, J; Li, ZP; Ban, YJ; Baiseitova, A; Park, KH Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle). Bioorg Med Chem27:2499-2507 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyphenol oxidase 2 |
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| Name: | Polyphenol oxidase 2 |
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| Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
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| Type: | Protein |
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| Mol. Mass.: | 63923.66 |
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| Organism: | Agaricus bisporus (Common mushroom) |
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| Description: | O42713 |
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| Residue: | 556 |
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| Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
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| BDBM50526625 |
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| n/a |
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| Name | BDBM50526625 |
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| Synonyms: | CHEMBL4592595 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22O10 |
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| Mol. Mass. | 482.4362 |
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| SMILES | [H][C@]12CO[C@]3(O)C1C(=CC([C@@H]2c1ccc(O)c(OC)c1)C3=O)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O |r,c:8,TLB:21:20:7.8:10.1,11:10:7.8:20.4,THB:3:4:7.8:10.1,2:1:7.8:20.4| |
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| Structure | 
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