| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proteasome subunit beta type-10 |
|---|
| Ligand | BDBM50329819 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1901152 (CHEMBL4403374) |
|---|
| IC50 | 10.0±n/a nM |
|---|
| Citation |  Xi, J; Zhuang, R; Kong, L; He, R; Zhu, H; Zhang, J Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases. Eur J Med Chem182:0 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proteasome subunit beta type-10 |
|---|
| Name: | Proteasome subunit beta type-10 |
|---|
| Synonyms: | LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 28940.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_106197 |
|---|
| Residue: | 273 |
|---|
| Sequence: | MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT
NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR
ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR
FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR
YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
|
|
|
|---|
| BDBM50329819 |
|---|
| n/a |
|---|
| Name | BDBM50329819 |
|---|
| Synonyms: | (R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutylboronic acid | CEP-18770 | CHEMBL270515 | [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(6-phenylpyridine-2-carbonyl)amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H28BN3O5 |
|---|
| Mol. Mass. | 413.275 |
|---|
| SMILES | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1cccc(n1)-c1ccccc1)[C@@H](C)O)B(O)O |
|---|
| Structure | 
|
|---|
Search and Browse
