| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
|---|
| Ligand | BDBM50527063 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1902006 (CHEMBL4404228) |
|---|
| IC50 | 210±n/a nM |
|---|
| Citation |  Peterková, L; Kmoní?ková, E; Ruml, T; Rimpelová, S Sarco/Endoplasmic Reticulum Calcium ATPase Inhibitors: Beyond Anticancer Perspective. J Med Chem63:1937-1963 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
|---|
| Name: | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
|---|
| Synonyms: | AT2A1_RABIT | ATP2A1 | Sarco/endoplasmic Reticulum Ca2+ ATPase 1 | Sarcoplasmic/endoplasmic reticulum calcium ATP-ase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 110435.34 |
|---|
| Organism: | Oryctolagus cuniculus |
|---|
| Description: | ChEMBL_1500621 |
|---|
| Residue: | 1001 |
|---|
| Sequence: | MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLWELVIEQFEDL
LVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALK
EYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSIL
TGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMA
ATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDKPIRSGQFDGLVELATICALC
NDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRNLSKVERANACNSVIRQLMK
KEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGP
VKEKILSVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGML
DPPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDD
LPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAM
GSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA
LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAI
GGYVGAATVGAAAWWFMYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAPEPMTMA
LSVLVTIEMCNALNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLK
ALDLTQWLMVLKISLPVIGLDEILKFIARNYLEDPEDERRK
|
|
|
|---|
| BDBM50527063 |
|---|
| n/a |
|---|
| Name | BDBM50527063 |
|---|
| Synonyms: | CHEMBL4534285 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H50O12 |
|---|
| Mol. Mass. | 650.7536 |
|---|
| SMILES | [H][C@@]12OC(=O)[C@@](C)(O)[C@@]1(O)[C@H](C[C@@](C)(OC(C)=O)[C@@]1([H])[C@H](OC(=O)CCCCCCC)[C@@H](OC(=O)C(\C)=C/C)C(C)=C21)OC(=O)CCC |r,t:41| |
|---|
| Structure | 
|
|---|
Search and Browse
