| Reaction Details |
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 | Report a problem with these data |
| Target | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
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| Ligand | BDBM50527063 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1902008 (CHEMBL4404230) |
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| IC50 | 210±n/a nM |
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| Citation |  Peterková, L; Kmoní?ková, E; Ruml, T; Rimpelová, S Sarco/Endoplasmic Reticulum Calcium ATPase Inhibitors: Beyond Anticancer Perspective. J Med Chem63:1937-1963 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
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| Name: | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
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| Synonyms: | 7.2.2.10 | AT2A3_HUMAN | ATP2A3 | Calcium pump 3 | SERCA3 | SR Ca(2+)-ATPase 3 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 109240.88 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_10715 |
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| Residue: | 999 |
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| Sequence: | MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDL
LVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALK
EYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSIL
TGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA
AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALC
NDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMR
KEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPT
SREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGML
DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDD
LSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAM
GSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAI
LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAI
GVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMA
LSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVT
PLSGRQWVVVLQISLPVILLDEALKYLSRNHMHEEMSQK
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| BDBM50527063 |
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| n/a |
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| Name | BDBM50527063 |
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| Synonyms: | CHEMBL4534285 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H50O12 |
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| Mol. Mass. | 650.7536 |
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| SMILES | [H][C@@]12OC(=O)[C@@](C)(O)[C@@]1(O)[C@H](C[C@@](C)(OC(C)=O)[C@@]1([H])[C@H](OC(=O)CCCCCCC)[C@@H](OC(=O)C(\C)=C/C)C(C)=C21)OC(=O)CCC |r,t:41| |
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| Structure | 
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