| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ZAP-70 |
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| Ligand | BDBM50082330 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_217767 |
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| IC50 | 22000±n/a nM |
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| Citation |  Vu, CB; Corpuz, EG; Pradeepan, SG; Violette, S; Bartlett, C; Sawyer, TK Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70. Bioorg Med Chem Lett9:3009-14 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ZAP-70 |
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| Name: | Tyrosine-protein kinase ZAP-70 |
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| Synonyms: | 70 kDa zeta-associated protein | SRK | Syk-related tyrosine kinase | Tyrosine Kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 (Syk) | Tyrosine-protein kinase ZAP-70 (ZAP70) | Tyrosine-protein kinase ZAP70 | ZAP70 | ZAP70_HUMAN | Zeta-chain (TCR) associated protein kinase 70kDa |
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| Type: | Enzyme |
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| Mol. Mass.: | 69881.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ZAP-70 SH2 domain was expressed and purified from E. coli using O-phospho-L-tyrosine-agarose column. |
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| Residue: | 619 |
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| Sequence: | MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT
SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR
KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG
PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF
GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY
KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL
ASKVEGPPGSTQKAEAACA
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| BDBM50082330 |
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| n/a |
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| Name | BDBM50082330 |
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| Synonyms: | 3-(4-Phosphonooxy-benzyl)-N-{1-[3-(4-trifluoromethyl-benzyl)-[1,2,4]oxadiazol-5-yl]-ethyl}-succinamic acid | CHEMBL419539 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23F3N3O8P |
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| Mol. Mass. | 557.413 |
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| SMILES | C[C@H](NC(=O)[C@@H](CC(O)=O)Cc1ccc(OP(O)(O)=O)cc1)c1nc(Cc2ccc(cc2)C(F)(F)F)no1 |
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| Structure | 
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