Reaction Details |
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Target | Decaprenylphosphoryl-beta-D-ribose oxidase |
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Ligand | BDBM50528138 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1904470 (CHEMBL4406692) |
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IC50 | 1995±n/a nM |
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Citation | Balabon, O; Pitta, E; Rogacki, MK; Meiler, E; Casanueva, R; Guijarro, L; Huss, S; Lopez-Roman, EM; Santos-Villarejo, Á; Augustyns, K; Ballell, L; Aguirre, DB; Bates, RH; Cunningham, F; Cacho, M; Van der Veken, P Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-?-d-Ribose Oxidase (DprE1) Inhibitors. J Med Chem63:5367-5386 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Decaprenylphosphoryl-beta-D-ribose oxidase |
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Name: | Decaprenylphosphoryl-beta-D-ribose oxidase |
Synonyms: | DPRE1_MYCTU | Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase | Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit | Decaprenylphosphoryl-beta-D-ribose oxidase | FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase | dprE1 |
Type: | PROTEIN |
Mol. Mass.: | 50167.60 |
Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Description: | ChEMBL_116793 |
Residue: | 461 |
Sequence: | MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSY
GDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQ
VTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGL
TGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKS
GTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHY
SFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDS
RTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
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BDBM50528138 |
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n/a |
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Name | BDBM50528138 |
Synonyms: | CHEMBL4446492 |
Type | Small organic molecule |
Emp. Form. | C20H19F2N3O5S |
Mol. Mass. | 451.444 |
SMILES | CN(C)S(=O)(=O)c1ccc(cc1)C1(C)NC(=O)N(CC(=O)c2ccc(F)cc2F)C1=O |
Structure |
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