| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacylase sirtuin-6 |
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| Ligand | BDBM50528218 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1904594 (CHEMBL4406952) |
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| EC50 | 10300±n/a nM |
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| Citation |  Lu, S; He, X; Ni, D; Zhang, J Allosteric Modulator Discovery: From Serendipity to Structure-Based Design. J Med Chem62:6405-6421 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacylase sirtuin-6 |
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| Name: | NAD-dependent protein deacylase sirtuin-6 |
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| Synonyms: | NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6) |
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| Type: | Protein |
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| Mol. Mass.: | 39133.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8N6T7 |
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| Residue: | 355 |
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| Sequence: | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG
IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV
RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE
LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN
LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPK
EESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
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| BDBM50528218 |
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| n/a |
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| Name | BDBM50528218 |
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| Synonyms: | CHEMBL4551664 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16BrCl2FN2O6S2 |
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| Mol. Mass. | 626.3 |
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| SMILES | COC(=O)c1cc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)ccc1S(=O)(=O)Nc1cc(Br)c(F)cc1C |
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| Structure | 
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