| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 3 |
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| Ligand | BDBM50528381 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1904874 (CHEMBL4407232) |
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| IC50 | 100±n/a nM |
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| Citation |  Cortés-Benítez, F; Roy, J; Perreault, M; Maltais, R; Poirier, D A- and D-Ring Structural Modifications of an Androsterone Derivative Inhibiting 17?-Hydroxysteroid Dehydrogenase Type 3: Chemical Synthesis and Structure-Activity Relationships. J Med Chem62:7070-7088 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase type 3 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase type 3 |
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| Synonyms: | 17-beta-hydroxysteroid dehydrogenase type 3 | DHB3_HUMAN | EDH17B3 | Estradiol 17-beta-dehydrogenase 3 | HSD17B3 | SDR12C2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 34525.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37058 |
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| Residue: | 310 |
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| Sequence: | MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL
AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI
LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN
TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV
AYLKLNTKVR
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| BDBM50528381 |
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| n/a |
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| Name | BDBM50528381 |
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| Synonyms: | CHEMBL4468509 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H37F3N2O4S |
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| Mol. Mass. | 602.707 |
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| SMILES | [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])c3ccc(cc3CC[C@@]21[H])C(=O)N1CC(C)N(CC1C)S(=O)(=O)c1ccccc1C(F)(F)F |r| |
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| Structure | 
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