| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15B |
|---|
| Ligand | BDBM50528945 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1906828 (CHEMBL4409186) |
|---|
| IC50 | 460±n/a nM |
|---|
| Citation |  Czyzyk, DJ; Valhondo, M; Deiana, L; Tirado-Rives, J; Jorgensen, WL; Anderson, KS Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur J Med Chem183:0 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyunsaturated fatty acid lipoxygenase ALOX15B |
|---|
| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15B |
|---|
| Synonyms: | Alox15b | Arachidonate 15-lipoxygenase, type II | LX15B_RAT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 76140.88 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_12426 |
|---|
| Residue: | 677 |
|---|
| Sequence: | MAKFRVRVSTGEACGAGTWDKVSVSIVGTHGESPLVPLDHLGKEFSAGAEEDFEVTLPQD
VGTVLMLRIHKAPPEAPLPLLSFPPDAWYCRWFELEWLPGAALRFPCYQWLEGAGELVLR
EGAAKVSWQDHHRTLQDQRQKELESRKDMYSWKTYIEGWPHCLDHETVKDLDLNIKYSAM
KNAKFFFKAQSAFTELKFKGLLDRTGLWRSLREMKRMFNFHNTPAAEYVFAHWQEDAFFA
SQFLNGLNPVLIRRCRRLPENFPVTDEMVAPVLGPGTSLQAELEKGSLFLVDHGILSGVQ
TNVINGKPQFSAAPMTLLYQSPGSGPLLPIAIQLKQTPGPDNPIFLPSDDKWDWLLAKTW
VRNAEFSIHEALTHLLHAHLIPEVFALATLRQLPHCHPLFKLLIPHTRYTLHINTLAREL
LIAPGKVVDKSTGLGIGGFSDLIKRNMEQLSYSVLCLPEDIRARDVGDLPGYYYRDDGMQ
IWSAIRSFVSEIVDIYYPSDASVRDDQELQAWVGEIFSEGFLSQESSGMPSLLDTQEALV
QYVTMVIFTCSAKHAAVSASQFDSCVWMPNLPPSMQLPPPTSKGQASPEGFIATLPAVNA
TCDVIIALWLLSKEPGDRRPLGHYPDEHFTEEVPRRSIAAFQRKLIQISSGIRKRNQSLA
LPYTYLDPPLIENSVSI
|
|
|
|---|
| BDBM50528945 |
|---|
| n/a |
|---|
| Name | BDBM50528945 |
|---|
| Synonyms: | CHEMBL4565065 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H16N6O4 |
|---|
| Mol. Mass. | 428.4002 |
|---|
| SMILES | Nc1nc2[nH]cc(Cc3ccc(cc3)C(=O)Nc3cc(ccc3C(O)=O)C#N)c2c(=O)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
