| Reaction Details |
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 | Report a problem with these data |
| Target | Target of rapamycin complex 2 subunit MAPKAP1 |
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| Ligand | BDBM50529393 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1908593 (CHEMBL4410951) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Ouvry, G; Clary, L; Tomas, L; Aurelly, M; Bonnary, L; Borde, E; Bouix-Peter, C; Chantalat, L; Defoin-Platel, C; Deret, S; Forissier, M; Harris, CS; Isabet, T; Lamy, L; Luzy, AP; Pascau, J; Soulet, C; Taddei, A; Taquet, N; Thoreau, E; Varvier, E; Vial, E; Hennequin, LF Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. ACS Med Chem Lett10:1561-1567 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Target of rapamycin complex 2 subunit MAPKAP1 |
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| Name: | Target of rapamycin complex 2 subunit MAPKAP1 |
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| Synonyms: | MAPKAP1 | MIP1 | Mitogen-activated protein kinase 2-associated protein 1 | SAPK-interacting protein 1 | SIN1 | SIN1_HUMAN | Stress-activated map kinase-interacting protein 1 | TORC2 subunit MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | mSIN1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59129.70 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119716 |
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| Residue: | 522 |
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| Sequence: | MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE
TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL
KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY
LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE
VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT
MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD
GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS
TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL
KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
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| BDBM50529393 |
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| n/a |
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| Name | BDBM50529393 |
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| Synonyms: | CHEMBL4564479 | US11731973, Example 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15N7O |
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| Mol. Mass. | 309.3259 |
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| SMILES | CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2cnc(N)nc12 |
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| Structure | 
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