| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl endopeptidase |
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| Ligand | BDBM50529485 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1908756 (CHEMBL4411114) |
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| IC50 | 28800±n/a nM |
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| Citation |  Kilpeläinen, TP; Tyni, JK; Lahtela-Kakkonen, MK; Eteläinen, TS; Myöhänen, TT; Wallén, EAA Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors. ACS Med Chem Lett10:1635-1640 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl endopeptidase |
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| Name: | Prolyl endopeptidase |
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| Synonyms: | PE | PPCE_MOUSE | Pep | Post-proline cleaving enzyme | Prep |
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| Type: | PROTEIN |
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| Mol. Mass.: | 80738.55 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1336164 |
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| Residue: | 710 |
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| Sequence: | MLSFQYPDVYRDETSVQEYHGHKICDPYSWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNTLS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFTCMAWTH
DGKGMFYNSYPQQDGKSDGTETSTNLHQKLCYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIWEGCDPVNRLWYCDLQQEPNGITGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRNSPNYRLINIDFTDPDESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNI
LQLHDLTTGALLKTFPLDVGSVVGYSGRKKDSEIFYQFTSFLSPGVIYHCDLTKEELEPM
VFREVTVKGIDAADYQTIQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKFTIGHAWTTDYG
CSDTKQHFEWLLKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIEWIQ
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| BDBM50529485 |
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| n/a |
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| Name | BDBM50529485 |
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| Synonyms: | CHEMBL4475037 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H27N3O3 |
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| Mol. Mass. | 345.436 |
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| SMILES | C[C@H](N(C)C(=O)CCCc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O |r| |
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| Structure | 
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