| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol kinase alpha |
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| Ligand | BDBM50529936 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1910956 (CHEMBL4413402) |
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| IC50 | 600±n/a nM |
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| Citation |  Velnati, S; Ruffo, E; Massarotti, A; Talmon, M; Varma, KSS; Gesu, A; Fresu, LG; Snow, AL; Bertoni, A; Capello, D; Tron, GC; Graziani, A; Baldanzi, G Identification of a novel DGK? inhibitor for XLP-1 therapy by virtual screening. Eur J Med Chem164:378-390 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol kinase alpha |
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| Name: | Diacylglycerol kinase alpha |
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| Synonyms: | 2.7.1.107 | 80 kDa diacylglycerol kinase | DAG kinase alpha | DAGK | DAGK1 | DGK-alpha | DGKA | DGKA_PIG | Diacylglycerol kinase alpha | Diglyceride kinase alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82605.19 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_118945 |
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| Residue: | 734 |
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| Sequence: | MSKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAEYLQGDAIGYEGFQQFLKIY
LEVDSVPSHLSLALFQSFQTSYCSEETVKRDVVCLSDVSCYFSLLEGGRPEDKLEFTFKL
YDTDRNGILDSSEVDRIIIQMMRMAEYLDWDVSELRPILQEMMKEIDYDGSGSVSLAEWL
RAGATTVPLLVLLGLEMTLKDNGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYT
VHDQCAMKALPCEVSTYAKSRKDIGVQTHVWVRGGCESGRCDRCQKKIRIYHSLVGLHCV
WCHLEIHDDCLPAMGHECDCGLLRDHILPPSSIYPSVLASGQERKVSKTSQKTTDDLNLS
TSEALRIDPVSNTHPLLVFVNPKSGGKQGERVLWKFQYLLNPRQVFNLLKDGPEPGLRFF
REVPDYRILVCGGDGTVGWILETIDKANLPFVPPVAVLPLGTGNDLARCLRWGGGYEGQN
LGKILKDLEASKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMR
EKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLN
IPSTHGGSNLWGDTKRPHGDIHGINQALGAMAKVITDPDILKTCVPDLSDKRLEVVGLEG
AIEMGQIYTKLKNAGHRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHRNQMPMLV
GPPPRSSNFFGFLC
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| BDBM50529936 |
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| n/a |
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| Name | BDBM50529936 |
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| Synonyms: | CHEMBL4558937 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12N2O4S3 |
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| Mol. Mass. | 392.472 |
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| SMILES | O=C1N(NS(=O)(=O)c2ccccc2)C(=S)S\C1=C\C=C\c1ccco1 |
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| Structure | 
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