| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol kinase alpha |
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| Ligand | BDBM50529938 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1910941 (CHEMBL4413387) |
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| IC50 | 19700±n/a nM |
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| Citation |  Velnati, S; Ruffo, E; Massarotti, A; Talmon, M; Varma, KSS; Gesu, A; Fresu, LG; Snow, AL; Bertoni, A; Capello, D; Tron, GC; Graziani, A; Baldanzi, G Identification of a novel DGK? inhibitor for XLP-1 therapy by virtual screening. Eur J Med Chem164:378-390 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol kinase alpha |
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| Name: | Diacylglycerol kinase alpha |
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| Synonyms: | 2.7.1.107 | 80 kDa diacylglycerol kinase | DAG kinase alpha | DAGK | DAGK1 | DGK-alpha | DGKA | DGKA_HUMAN | Diglyceride kinase alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82631.86 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117392 |
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| Residue: | 735 |
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| Sequence: | MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY
LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK
LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW
VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY
TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC
VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL
STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL
FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ
NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM
REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL
NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE
GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML
MGPPPRSTNFFGFLS
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| BDBM50529938 |
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| n/a |
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| Name | BDBM50529938 |
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| Synonyms: | CHEMBL259388 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26FN3OS |
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| Mol. Mass. | 459.578 |
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| SMILES | [#6]-c1nc2sccn2c(=O)c1-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccccc1)-c1ccc(F)cc1 |
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| Structure | 
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