Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Casein kinase II subunit alpha | ||
| Ligand | BDBM50530332 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1911832 (CHEMBL4414278) | ||
| IC50 | 7000±n/a nM | ||
| Citation |  Bestgen, B; Krimm, I; Kufareva, I; Kamal, AAM; Seetoh, WG; Abell, C; Hartmann, RW; Abagyan, R; Cochet, C; Le Borgne, M; Engel, M; Lomberget, T 2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site. J Med Chem62:1803-1816 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Casein kinase II subunit alpha | |||
| Name: | Casein kinase II subunit alpha | ||
| Synonyms: | CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 45151.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P68400 | ||
| Residue: | 391 | ||
| Sequence: |
| ||
| BDBM50530332 | |||
| n/a | |||
| Name | BDBM50530332 | ||
| Synonyms: | CHEMBL4439686 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23Cl2N3 | ||
| Mol. Mass. | 424.366 | ||
| SMILES | CCc1ccccc1-c1c(Cl)cc(CNCCc2nc3ccccc3[nH]2)cc1Cl |(16,-37.2,;14.66,-36.43,;13.33,-37.2,;13.34,-38.74,;12,-39.52,;10.67,-38.75,;10.67,-37.21,;12,-36.44,;12,-34.9,;10.67,-34.13,;9.33,-34.9,;10.67,-32.59,;12,-31.82,;11.99,-30.28,;13.32,-29.5,;13.32,-27.96,;14.65,-27.19,;14.65,-25.65,;15.88,-24.74,;15.4,-23.27,;16.16,-21.94,;15.39,-20.62,;13.85,-20.63,;13.09,-21.96,;13.86,-23.28,;13.39,-24.74,;13.33,-32.58,;13.34,-34.13,;14.67,-34.9,)| | ||
| Structure | 
| ||