| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1B |
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| Ligand | BDBM50086106 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1774 (CHEMBL616558) |
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| IC50 | 133±n/a nM |
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| Citation |  Matzen, L; van Amsterdam, C; Rautenberg, W; Greiner, HE; Harting, J; Seyfried, CA; Böttcher, H 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants. J Med Chem43:1149-57 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1B |
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| Name: | 5-hydroxytryptamine receptor 1B |
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| Synonyms: | 5-HT-1B | 5-HT1B | 5-hydroxytryptamine receptor 1B (5HT1B) | 5HT1B_RAT | 5ht1b | Htr1b | Serotonin 1 (5-HT1) receptor | Serotonin 1B/1D receptor | Serotonin receptor 1B |
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| Type: | Protein |
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| Mol. Mass.: | 43173.33 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P28564 |
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| Residue: | 386 |
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| Sequence: | MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATT
LSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDF
WLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPP
FFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTP
NKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKL
MAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLI
NPIIYTMSNEDFKQAFHKLIRFKCTG
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| BDBM50086106 |
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| n/a |
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| Name | BDBM50086106 |
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| Synonyms: | 1-[3-(2-Dimethylamino-ethoxy)-4-methoxy-phenyl]-3-{2-[4-(6-fluoro-1H-indol-3-yl)-piperidin-1-yl]-ethyl}-urea | CHEMBL279320 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H36FN5O3 |
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| Mol. Mass. | 497.6048 |
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| SMILES | COc1ccc(NC(=O)NCCN2CCC(CC2)c2c[nH]c3cc(F)ccc23)cc1OCCN(C)C |
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| Structure | 
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