| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50531605 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1920499 (CHEMBL4423344) |
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| Ki | 58±n/a nM |
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| Citation |  Uprety, R; Váradi, A; Allaoa, A; Redel-Traub, GN; Palmer, TC; Feinberg, EN; Ferris, AC; Pande, VS; Pasternak, GW; Majumdar, S Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (? Eur J Med Chem164:241-251 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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| BDBM50531605 |
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| n/a |
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| Name | BDBM50531605 |
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| Synonyms: | CHEMBL4552298 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H25N3O3 |
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| Mol. Mass. | 331.4094 |
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| SMILES | CN1CCC2(CC1)N[C@@H](CO)C(=O)N(C2=O)c1c(C)cccc1C |r| |
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| Structure | 
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