| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM50531739 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1920785 (CHEMBL4423630) |
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| Ki | 20±n/a nM |
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| Citation |  de Moura Sperotto, ND; Deves Roth, C; Rodrigues-Junior, VS; Ev Neves, C; Reisdorfer Paula, F; da Silva Dadda, A; Bergo, P; Freitas de Freitas, T; Souza Macchi, F; Moura, S; Duarte de Souza, AP; Campos, MM; Valim Bizarro, C; Santos, DS; Basso, LA; Machado, P Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer. J Med Chem62:1231-1245 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 49948.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
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| Residue: | 482 |
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| Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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| BDBM50531739 |
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| n/a |
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| Name | BDBM50531739 |
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| Synonyms: | MA-1 | TPI (freebase) | Tipiracil |
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| Type | Small organic molecule |
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| Emp. Form. | C9H11ClN4O2 |
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| Mol. Mass. | 242.662 |
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| SMILES | Oc1nc(O)c(Cl)c(CN2CCCC2=N)n1 |
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| Structure | 
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