| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 72 kDa type IV collagenase |
|---|
| Ligand | BDBM50088089 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_104538 (CHEMBL718925) |
|---|
| Ki | 1.8±n/a nM |
|---|
| Citation |  Scozzafava, A; Supuran, CT Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties. J Med Chem43:1858-65 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 72 kDa type IV collagenase |
|---|
| Name: | 72 kDa type IV collagenase |
|---|
| Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 73870.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08253 |
|---|
| Residue: | 660 |
|---|
| Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
|
|
|
|---|
| BDBM50088089 |
|---|
| n/a |
|---|
| Name | BDBM50088089 |
|---|
| Synonyms: | CHEMBL55984 | N-Hydroxy-2-[(4-nitro-benzyl)-(3-(N-(4-Fluoro-benzene)-sulfonyl)ureido-benzenesulfonyl)-amino]-acetamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H20FN5O9S2 |
|---|
| Mol. Mass. | 581.551 |
|---|
| SMILES | ONC(=O)CN(Cc1ccc(cc1)[N+]([O-])=O)S(=O)(=O)c1cccc(NC(=O)NS(=O)(=O)c2ccc(F)cc2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
