| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil collagenase |
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| Ligand | BDBM50088082 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_105807 (CHEMBL718141) |
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| Ki | 2.1±n/a nM |
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| Citation |  Scozzafava, A; Supuran, CT Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties. J Med Chem43:1858-65 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil collagenase |
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| Name: | Neutrophil collagenase |
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| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
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| Type: | Enzyme |
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| Mol. Mass.: | 53413.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22894 |
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| Residue: | 467 |
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| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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| BDBM50088082 |
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| n/a |
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| Name | BDBM50088082 |
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| Synonyms: | CHEMBL53847 | N-Hydroxy-2-[(4-nitro-benzyl)-(3-(N-(4-methyl-benzene)-sulfonyl)ureido-benzenesulfonyl)-amino]-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N5O9S2 |
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| Mol. Mass. | 577.587 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc1cccc(c1)S(=O)(=O)N(CC(=O)NO)Cc1ccc(cc1)[N+]([O-])=O |
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| Structure | 
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