| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50532590 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1923367 (CHEMBL4426323) |
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| IC50 | 1.000000±n/a nM |
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| Citation |  Boss, C; Bolli, MH; Gatfield, J From bosentan (TracleerŪ) to macitentan (OpsumitŪ): The medicinal chemistry perspective. Bioorg Med Chem Lett26:3381-94 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50532590 |
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| n/a |
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| Name | BDBM50532590 |
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| Synonyms: | CHEMBL4549357 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32N6O8S2 |
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| Mol. Mass. | 656.73 |
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| SMILES | COc1ccccc1Oc1c(NS(=O)(=O)CCc2cccs2)nc(nc1OCCOC(=O)Nc1ccccn1)N1CCOCC1 |
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| Structure | 
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