| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-serine O-palmitoleoyltransferase porcupine |
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| Ligand | BDBM375004 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1924452 (CHEMBL4427408) |
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| IC50 | 0.200000±n/a nM |
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| Citation |  Cheng, D; Liu, J; Han, D; Zhang, G; Gao, W; Hsieh, MH; Ng, N; Kasibhatla, S; Tompkins, C; Li, J; Steffy, A; Sun, F; Li, C; Seidel, HM; Harris, JL; Pan, S Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS Med Chem Lett7:676-80 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-serine O-palmitoleoyltransferase porcupine |
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| Name: | Protein-serine O-palmitoleoyltransferase porcupine |
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| Synonyms: | PORCN_MOUSE | Porc | Porcn | Ppn | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein-cysteine N-palmitoyltransferase porcupine | mPORC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52528.36 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_941167 |
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| Residue: | 461 |
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| Sequence: | MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGG
FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
HKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
QGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVR
WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVE
VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
EHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVD
VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
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| BDBM375004 |
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| n/a |
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| Name | BDBM375004 |
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| Synonyms: | 2-(2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide | US10251893, Cpd 199 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17FN6O |
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| Mol. Mass. | 400.4084 |
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| SMILES | Cc1cc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cnc1-c1ccnc(F)c1 |
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| Structure | 
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