| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endoplasmic reticulum aminopeptidase 1 |
|---|
| Ligand | BDBM50533145 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1924486 (CHEMBL4427442) |
|---|
| IC50 | 43000±n/a nM |
|---|
| Citation |  Stamogiannos, A; Papakyriakou, A; Mauvais, FX; van Endert, P; Stratikos, E Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1. ACS Med Chem Lett7:681-5 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endoplasmic reticulum aminopeptidase 1 |
|---|
| Name: | Endoplasmic reticulum aminopeptidase 1 |
|---|
| Synonyms: | APPILS | ARTS1 | Aminopeptidase | ERAP1 | ERAP1_HUMAN | KIAA0525 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 107232.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1473167 |
|---|
| Residue: | 941 |
|---|
| Sequence: | MVFLPLKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIP
VHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSEEPL
QVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILAST
QFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTV
KMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIP
YPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWF
GNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSHPVS
TPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWD
SMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGR
NVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKF
NVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDL
SLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEG
SVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTE
GWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIG
RNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKE
NGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEKLERM
|
|
|
|---|
| BDBM50533145 |
|---|
| n/a |
|---|
| Name | BDBM50533145 |
|---|
| Synonyms: | CHEMBL4468391 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H21N5O2 |
|---|
| Mol. Mass. | 435.4772 |
|---|
| SMILES | O=C(N\N=C\c1c[nH]c2ccccc12)c1cc(n[nH]1)-c1ccc(OCc2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
