| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50533525 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1925694 (CHEMBL4428766) |
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| IC50 | 66±n/a nM |
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| Citation |  Rynearson, KD; Buckle, RN; Barnes, KD; Herr, RJ; Mayhew, NJ; Paquette, WD; Sakwa, SA; Nguyen, PD; Johnson, G; Tanzi, RE; Wagner, SL Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. Bioorg Med Chem Lett26:3928-37 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50533525 |
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| n/a |
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| Name | BDBM50533525 |
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| Synonyms: | CHEMBL4551156 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23FN6S |
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| Mol. Mass. | 422.522 |
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| SMILES | CC(C)n1nc2CCCc2c1Nc1nc(cs1)-c1ccc(c(F)c1)-n1cnc(C)c1 |
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| Structure | 
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