| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipase A2, membrane associated |
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| Ligand | BDBM50534280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1928081 (CHEMBL4431153) |
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| IC50 | 110±n/a nM |
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| Citation |  Giordanetto, F; Pettersen, D; Starke, I; Nordberg, P; Dahlström, M; Knerr, L; Selmi, N; Rosengren, B; Larsson, LO; Sandmark, J; Castaldo, M; Dekker, N; Karlsson, U; Hurt-Camejo, E Discovery of AZD2716: A Novel Secreted Phospholipase A ACS Med Chem Lett7:884-889 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phospholipase A2, membrane associated |
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| Name: | Phospholipase A2, membrane associated |
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| Synonyms: | GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A |
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| Type: | Hydrolase |
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| Mol. Mass.: | 16101.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification. |
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| Residue: | 144 |
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| Sequence: | MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
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| BDBM50534280 |
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| n/a |
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| Name | BDBM50534280 |
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| Synonyms: | CHEMBL4591759 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23NO3 |
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| Mol. Mass. | 373.4443 |
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| SMILES | NC(=O)c1ccc(Cc2ccccc2)cc1-c1cccc(CCCC(O)=O)c1 |
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| Structure | 
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