| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50534337 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1928186 (CHEMBL4431258) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Ingham, OJ; Paranal, RM; Smith, WB; Escobar, RA; Yueh, H; Snyder, T; Porco, JA; Bradner, JE; Beeler, AB Development of a Potent and Selective HDAC8 Inhibitor. ACS Med Chem Lett7:929-932 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50534337 |
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| n/a |
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| Name | BDBM50534337 |
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| Synonyms: | CHEMBL4566086 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21N5O2 |
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| Mol. Mass. | 411.4558 |
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| SMILES | ONC(=O)[C@H](Cc1c[nH]c2ccccc12)n1nnc(c1C#CC1CC1)-c1ccccc1 |r| |
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| Structure | 
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