| Reaction Details |
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 | Report a problem with these data |
| Target | Urease subunit beta |
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| Ligand | BDBM50534777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1929331 (CHEMBL4432507) |
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| IC50 | 25400±n/a nM |
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| Citation |  Macegoniuk, K; Grela, E; Palus, J; Rudzi?ska-Szostak, E; Grabowiecka, A; Biernat, M; Berlicki, ? 1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors. J Med Chem59:8125-33 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease subunit beta |
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| Name: | Urease subunit beta |
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| Synonyms: | 3.5.1.5 | URE1_HELPY | Urea amidohydrolase subunit beta | Urease subunit beta | hpuB | ureB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61676.43 |
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| Organism: | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
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| Description: | ChEMBL_117195 |
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| Residue: | 569 |
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| Sequence: | MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNN
PSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEA
LAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLK
WMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADK
YDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPAST
NPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITS
SDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGIS
EYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFA
HHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNP
ETYHVFVDGKEVTSKPANKVSLAQLFSIF
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| BDBM50534777 |
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| n/a |
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| Name | BDBM50534777 |
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| Synonyms: | CHEMBL4592440 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13NO3Se |
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| Mol. Mass. | 298.2 |
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| SMILES | [#6]-[#6](-[#6])-[#6@@H](-[#6](-[#8])=O)-n1[se;v2]c2ccccc2c1=O |r| |
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| Structure | 
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